研究業績_{（2006年以降）}

2017年

Ishikawa T, Kashima M, Nagano AJ, Ishikawa-Fujiwara T, Kamei Y, Todo T, Mori K.
Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish.
Elife. 2017 Sep 27;6. pii: e26845.10.1016/j.mce.2017.07.013.

Nakamoto M, Shibata Y, Ohno K, Usami T, Kamei Y, Taniguchi Y, Todo T, Sakamoto T, Young G, Swanson P, Naruse K, Nagahama Y.
Ovarian aromatase loss-of-function mutant medaka undergo ovary degeneration and partial female-to-male sex reversal after puberty.
Mol Cell Endocrinol. 2017 Jul 13. pii: S0303-7207(17)30367-2.10.1021/acs.biochem.6b00361.

Ishikawa T, Toyama T, Nakamura Y, Tamada K, Shimizu H, Ninagawa S, Okada T, Kamei Y, Ishikawa-Fujiwara T, Todo T, Aoyama E, Takigawa M, Harada A, Mori K.
OPR transducer BBF2H7 aallows export of type II collagen in a cargo- and development stage-specific manner.
J Cell Biol. 2017 May 12. pii: jcb.201609100.10.1083/jcb.201609100.

Uchida H, Nakamura TJ, Takasu NN, Obana-Koshino A, Ono H, Todo T, Sakai T, Nakamura W.
The central clock controls the daily rhythm of Apq5 expression in salivary glands.
J Physiol Sci. 2017 May 8. 10.1007/s12576-017-0540-1.

Ishikawa-Fujiwara T, Shiraishi E, Fujikawa Y, Mori T, Tsujimura T, Todo T.
Targeted Inactivation of DNA Photolyase Genes in Medaka Fish (Oryzias latipes).
Photochem Photobiol. 2017 Jan: 93(1):315-322.10.1111/php.12658.

2016年

Yamada D, Dokainish HM, Iwata T, Yamamoto J, Ishikawa T, Todo T, Iwai S, Getzoff ED, Kitao A, Kandori H.
Functional Conversion of CPD and (6-4) Photolyases by Mutation.
Biochemistry. 2016 Aug 2;55(30):4173-83.10.1021/acs.biochem.6b00361.

Nakajima H, Yamaguchi Y, Yoshimura T, Fukumoto M, Todo T. Fukushima
simulation experiment: assessing the effects of chronic low-dose-rate internal 137Cs radiation exposure on litter size, sex ratio, and biokinetics in mice.
J Radiat Res. 2015 Dec;56 Suppl 1:i29-i35.

Uchida H, Nakamura TJ, Takasu NN, Todo T, Sakai T, Nakamura W.
Cryptochrome-dependent circadian periods in the arcuate nucleus.
Neurosci Lett. Neurosci Lett. 2016 Jan 1;610:123-8.10.1016/j.neulet.2015.10.071.

2015年

Takasu NN, Nakamura TJ, Tokuda IT, Todo T, Block GD, Nakamura W.
Recovery from age-related infertility under environmental light-dark cycles adjusted to the intrinsic circadian period.
Cell Rep. 2015 Sep 1; 12(9): 1407-13. doi:10.1016/j.celrep.2015.07.049.

Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa-Fujiwara T, Matsui H, Naruse K, Sakamoto N, Uchiyama Y, Todo T, Takeda S, Yamakado H, Takahashi R.
Viable neuronopathic Gaucher sisease model in Medaka (Oryzias latipes) display axonal accumulation of Aipha-Synuclein.
PLoS Genet. 2015 Apr 2;11(4):e1005065. doi:10.1371/journal.pgen.1005065. eCollection 2015 Apr.

2014年

Hirano A, Kurabayashi N, Nakagawa T, Shioi G, Todo T, Hirota T, Fukada Y.
In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock.
Mol. Cell. Biol. 2014, 34(24):4464-73. DOI:10.1128/MCB.00711-14.

Murozumi N, Nakashima R, Hirai T, Kamei Y, Ishikawa-Fujiwara T, Todo T, Kitano T.
Loss of follicle-stimulating hormone receptor function causes masculinization and sippression of ovarian development in genetically female medaka.
Endocrinology. 2014 May 30 doi:en20132060.

Akashi M, Okamoto A, Tsuchiya Y, Todo T, Nishida E, Node K.
A Positive Role for PERIOD in Mammalian Circadian Gene Expression.
Cell Rep. (2014), S2211-1247 (14)00282-4, doi: 10.1016/j.celrep.2014.03.072.

Yasui T, Morii E, Yamamoto Y, Yoshii T, Takenaka Y, Nakahara S, Todo T, Inohara H.
Human papillomavirus and cystic node metastasis in oropharyyngeal cancer and cancer of unknown primary origin.
PLoS One. 2014 Apr 21;9(4):e95364. doi: 10.1371/journal.pone.0095364. eCollection 2014.

Akihiro Goriki, Fumiyuki Hatanaka, Jihwan Myung, Jae Kyoung Kim, Takashi Yoritaka, Shintaro Tanoue, Takaya Abe, Hiroshi Kiyonari, Katsumi Fujimoto, Yukio Kato, Takashi Todo, Akio Matsubara, Daniel Forger, Toru Takumi
A Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock.
PLoS Biol. 2014 12(4):e1001839. doi: 10.1371/journal.pbio.1001839.

Nakajima H, Fujiwara M, Tanihata I, Saito T, Matsuda N, Todo T.
Imaging plant leaves to determine changes in radioactive contamination status in Fukushima, Japan.
Health Phys. 2014 May;106(5):565-70. doi: 10.1097/HP.0000000000000020.

Maruyama H, Yasui T, Ishikawa-Fujiwara T, Morii E, Yamamoto Y, Yoshii T, Takenaka Y, Nakahara S, Todo T, Hongyo T, Inohara H.
Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.
Cancer Sci. 2014 Feb 13. doi: 10.1111/cas.12369.

Oliveri P, Fortunato AE, Petrone L, Ishikawa-Fujiwara T, Kobayashi Y, Todo T, Antonova O, Arboleda E, Zantke J, Tessmar-Raible K, Falciatore A.
The Cryptochrome/Photolyase Family in aquatic organisms.
Mar Genomics, 2014 doi: 10.1016/j.margen.2014.02.001.

Otozai S, Ishikawa-Fujiwara T, Oda, S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, and Todo T,
p53-Dependent Suppression of Genome Instability in Germ Cells.
Mutat Res. (2014) 760:24-32 doi: 10.1016/j.mrfmmm.2013.12.004

2013年

Zantke J, Ishikawa-Fujiwara T, Arboleda E, Lohs C, Schipany K, Hallay N, Straw AD, Todo T, Tessmar-Raible K.
Circadian and Circalunar Clock Interactions in a Marine Annelid.
Cell Rep. (2013) 5(1):99-113
doi:pii: S2211-1247(13)00472-5. 10.1016/j.celrep.2013.08.031.

Hashimoto K, Todo T, Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid.
Mutagenesis. (2013) 28(4) 457-64 doi: 10.1093/mutage/get021

Kadomatsu T, Uragami S, Akashi M, Tsuchiya Y, Nakajima H, Nakashima Y, Endo M, Miyata K, Terada K, Todo T, Node K, Oike Y.
A molecular clock regulates angiopoietin-like protein 2 expression.
PloS One, 2013;8(2):e57921. doi: 10.1371

Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K.
ATF6a/b-mediated adjustment of ER chaperone levels is essential for development of the Notchord in Medaka fish.
Mol Biol Cell. 2013 24(9):1387-1395.

2012年

Takasu NN, Kurosawa G, Tokuda IT, Mochizuki A, Todo T, Nakamura W.
Circadian regulation of food-anticipatory activity in molecular clock-deficient mice.
PLoS One. 2012;7(11):e48892. doi: 10.1371/journal.pone.0048892.

Yasuda T, Oda S, Li Z, Kimori Y, Kamei Y, Ishikawa T, Todo T, Mitani H.
Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medak (Oryzias latipes).
Cell Death Dis. 2012 Oct 4;3:e395. PubMed

Negoro H, Kanematsu A, Doi M, Suadicani SO, Matsuo M, Imamura M, Okinami T, Nishikawa N, Oura T, Matsui S, Seo K, Tainaka M, Urabe S, Kiyokage E, Todo T, Okamura H, Tabata Y, Ogawa O.
Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diumal micturition rhythm.
Nature Commun. 2012 May 1;3:809. doi: 10.1038/ncomms1812

Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, Hirayama J, Nishina H.
Involvement of the stress kinase mitogen-activated protein kinase kinase 7 in the regulation of the mammalian circadian clock.
J Biol Chem. 2012287(11):8318-26. 2012, doi: 10.1074/jbc.M111.308908

2011年

Masuyama H, Yamada M, Kamei Y, Fujiwara-Ishikawa T, Todo T, Nagahama Y, Matsuda M.
Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka.
Chromosome Res. (2011) 20(1):163-76PubMed

Kondoh M, Hitomi K, Yamamoto J, Todo T, Iwai S, Getzoff ED, Terazima M.
Light-induced conformational change and product release in DNA repair by (6-4)photolyase.
J Am Chem Soc. 2011 133(7):2183-91. PubMed

Nakajima H, Ozaki K, Hongyo T, Narama I, Todo T.
A rapid and easy method for the qualitative detection of intracellular deposition of inhaled nanoparticles.
Nanomedicine. (2011) 7(6):881-8 PubMed

Zhang Y, Iwata T, Yamamoto J, Hitomi K, Iwai S, Todo T, Getzoff ED, Kandori H.
FTIR Study of Light-Dependent Activation and DNA Repair Processes of (6-4) Photolyase.
Biochemistry. 2011 50(18):3591-8. PubMed

2010年

Ishikawa T, Kamei Y, Otozai S, Kim J, Sato A, Kuwahara Y, Tanaka M, Deguchi T, Inohara H, Tsujimura T, Todo T.
High-resolution melting curve analysis for rapid detection of mutations in a Medaka TILLING library
BMC Mol Biol. 2010 15;11(1):70 PubMed

Yamanaka Y, Suzuki Y, Todo T, Honma KI, Honma S.
Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice.
Genes Cells. 2010, 15(10), 1063-71 PubMed

Heijde M, Zabulon G, Corellou F, Ishikawa T, Brazard J, Usman A, Sanchez F, Plaza P, Martin M, Falciatore A, Todo T, Bouget FY, Bowler C.
Characterization of two members of the Cryptochrome/Photolyase Family from Ostreococcus tauri provides insights into the origin and evolution of cryptochromes.
Plant Cell Environ. 2010, 33(10), 1614-26 PubMed

Oda S, Mikami S, Urushihara Y, Murata Y, Kamei Y, Deguchi T, Kitano T, Fujimori KE, Yuba S, Todo T, Mitani H.
Identification of a functional medaka heat shock promoter and characterization of its ability to induce exogenous gene expression in medaka in vitro and in vivo.
Zoolog Sci. 2010 ;27(5):410-5. PubMed

Doi M, Takahashi Y, Komatsu R, Yamazaki F, Yamada H, Haraguchi S, Emoto N, Okuno Y, Tsujimoto G, Kanematsu A, Ogawa O, Todo T, Tsutsui K, van der Horst GT, Okamura H.
Self-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.
Nature Med. 2010 ;16(1):67-74 PubMed

2009年

Coesel S, Mangogna M, Ishikawa T, Heijde M, Rogato A, Finazzi G, Todo T, Bowler C, Falciatore A.
Diatom PtCPF1 is a new cryptochrome/photolyase family member with DNA repair and transcription regulation activity.
EMBO Rep. 2009 Jun;10(6):655-61 PubMed

Deguchi T, Itoh M, Urawa H, Matsumoto T, Nakayama S, Kawasaki T, Kitano T, Oda S, Mitani H, Takahashi T, Todo T, Sato J, Okada K, Hatta K, Yuba S, Kamei.
Infrared laser-mediated local gene induction in medaka, zebrafish and Arabidopsis thaliana.
Dev Growth Differ. (2009) 6(1):79-81 PubMed

Hirayama J, Miyamura N, Uchida Y, Asaoka Y, Honda R, Sawanobori K, Todo T, Yamamoto T, Sassone-Corsi P, Nishina H.
Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish.
Cell Cycle. (2009) 8(17):2794-801. PubMed

Hitomi K, DiTacchio L, Arvai AS, Yamamoto J, Kim ST, Todo T, Tainer JA, Iwai S, Panda S, Getzoff ED.
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes.
Proc Natl Acad Sci U S A. (2009)106(17):6962-7 PubMed

Kamei Y, Suzuki M, Watanabe K, Fujimori K, Kawasaki T, Deguchi T, Yoneda Y, Todo T, Takagi S, Funatsu T, Yuba S.
Infrared laser-mediated gene induction in targeted single cells in vivo.
Nat Methods. (2009) 6(1):79-81. PubMed

2008年

Zikihara K, Ishikawa T, Todo T, Tokutomi S.
Involvement of electron transfer in the photoreaction of zebrafish Cryptochrome-DASH.
Photochem Photobiol. (2008) 84(4):1016-23. PubMed

Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T.
DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex.　
J Biol Chem. (2008) 283(14):9071-9. PubMed

Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C.
Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons.
J Comp Neurol. 2008 ;508(6):952-66. PubMed

2007年

Kamei Y, Itou J, Oda S, Masui M, Kim JH, Ishikawa T, Yuba S, Kinoshita M, Mitani H, Todo T.
Development of a convenient in vitro fertilization method using interspecific hybrids between Oryzias latipes and Oryzias curvinotus.
Dev Growth Differ. (2007) 49(9):721-30. PubMed

Schleicher E, Hitomi K, Kay CW, Getzoff ED, Todo T, Weber S.
ENDOR differentiates complementary roles for active site histidines in (6-4) photolyase.
J Biol Chem. 2007, 282(7):4738-47. PubMed

Tanida M, Yamatodani A, Niijima A, Shen J, Todo T, Nagai K.
Autonomic and cardiovascular responses to scent stimulation are altered in cry KO mice.
Neurosci Lett. 2007, 413, 177-182. PubMed

Ikehata H., Ono T., Tanaka K., Todo T.
A model for triplet mutation formation based on error-prone translesional DNA synthesis opposite UV photolesions.
DNA Repair (Amst). 2007 6(5):658-68. PubMed

Ikeda H, Yong Q, Kurose T, Todo T, Mizunoya W, Fushiki T, Seino Y, Yamada Y.
Clock gene defect disrupts light-dependency of autonomic nerve activity.
Biochem Biophys Res Commun. 2007 364(3), 457-63. PubMed

2006年

Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, DeguchiT,Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E.
Generation of medaka gene knockout models by target-selected mutagenesis.
Genome Biol. 2006, 7(12):R116. PubMed

H. Mitani, Y. Kamei, S. Fukamachi, S.Oda, T. Sasaki, S. Asakawa, T. Todo, N. Shimizu
Medaka: a model fish in comparative and functional genomics.
Genome Dyn. 2006;2:165-82.（Review）

Abe T, Ishikawa T, Masuda T, Mizusawa K, Tsukamoto T, Mitani H, Yanagisawa T, Todo T, Iigo M.
Molecular analysis of Dec1 and Dec2 in the peripheral circadian clock of zebrafish photosensitive cells.　
Biochem Biophys Res Commun. (2006) 351(4):1072-7. PubMed

Rochette PJ, Bastien N, Todo T, Drouin R.
Pyrimidine (6-4) Pyrimidone Photoproduct Mapping After Sub-lethal UVC Doses: Nucleotide Resolution Using Terminal Transferase-dependent PCR.
Photochem Photobiol. 2006 82(5), 1370-6 PubMed

Li J, Uchida T, Todo T, Kitagawa T.
Similarities and differences between cyclobutane pyrimidine dimer (CPD) photolyase and (6-4) photolyase as revealed by resonance Raman spectroscopy : Electron transfer mechanism from FAD cofactor to UV-damaged DNA.
J Biol Chem. 281(35):25551-9. 2006 PubMed

Li J, Uchida T, Ohta T, Todo T, Kitagawa T.
Characteristic Structure and Environment in FAD Cofactor of (6-4) Photolyase along Function Revealed by Resonance Raman Spectroscopy.
J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2006 110(33):16724-16732. PubMed

Zikihara K, Iwata T, Matsuoka D, Kandori H, Todo T, Tokutomi S.
Photoreaction cycle of the light, oxygen, and voltage domain in FKF1 determined by low-temperature absorption spectroscopy.
Biochemistry. 2006 45(36)10828-37 PubMed

Yamamoto J, Hitomi K, Todo T, Iwai S:
Chemical synthesis ofoligodeoxyribonucleotides containing the Dewar valence isomer of the (6-4) photoproduct and their use in (6-4) photolyase studies.
Nucleic Acids Res. 2006 34(16):4406-15 PubMed

Maeda A, Tsujiya S, Higashide T, Toida K, Todo T, Ueyama T, Okamura H, Sugiyama K.
Circadian intraocular pressure rhythm is generated by clock genes.
Invest Ophthalmol Vis Sci. 2006, 47(9):4050-2. PubMed

2005年以前の代表的論文

C. Lin, T. Todo The cryptochromes. Genome Biol. (2005)6(5):220 （Review）

T. Todo Functional diversity of the DNA photolyase / blue light receptor family. Mutat. Res. (1993) 434, 89-97（Review）PubMed

T. Todo, H. Ryo, K. Yamamoto, H. Toh, T. Inui, H. Ayaki, T. Nomura and M. Ikenaga Similarity among the Drosophila (6-4)photolyase, a human homolog, and the DNA photolyase Blue-light photoreceptor family. Science 272, 109-112 (1996) PubMed

T. Todo, H. Takemori, H. Ryo, M. Ihara, T. Matsunaga, O. Nikaido, K. Sato and T. Nomura A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts. Nature 361, 371-374 (1993) PubMed